SLC12A6 and STK39

Data Source:
HPRD (two hybrid)

		SLC12A6	STK39
Description		solute carrier family 12 member 6	serine/threonine kinase 39
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Synapse	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ammonium Transmembrane Transporter Activity Potassium:chloride Symporter Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Angiogenesis Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Cellular Hypotonic Salinity Response Ammonium Import Across Plasma Membrane Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
Drugs		Potassium chloride	Fostamatinib
Diseases		Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
GWAS		Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)	Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		3 interacting genes: DYSF OXSR1 STK39	14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4
Entrez ID		9990	27347
HPRD ID		09220	09627
Ensembl ID		ENSG00000140199	ENSG00000198648
Uniprot IDs		A0A024R9I5 A0A024R9K8 Q6NSI7 Q9UHW9	Q9UEW8
PDB IDs		6M1Y 6M22 6Y5R 6Y5V
Enriched GO Terms of Interacting Partners?
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