STK39 and SLC12A6

Data Source:
HPRD (two hybrid)

		STK39	SLC12A6
Description		serine/threonine kinase 39	solute carrier family 12 member 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ammonium Transmembrane Transporter Activity Potassium:chloride Symporter Activity
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Angiogenesis Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Cellular Hypotonic Salinity Response Ammonium Import Across Plasma Membrane Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
Drugs		Fostamatinib	Potassium chloride
Diseases			Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
GWAS		Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)	Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)
Interacting Genes		14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4	3 interacting genes: DYSF OXSR1 STK39
Entrez ID		27347	9990
HPRD ID		09627	09220
Ensembl ID		ENSG00000198648	ENSG00000140199
Uniprot IDs		Q9UEW8	A0A024R9I5 A0A024R9K8 Q6NSI7 Q9UHW9
PDB IDs			6M1Y 6M22 6Y5R 6Y5V
Enriched GO Terms of Interacting Partners?
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