STK39 and OTOF

Data Source:
BioGRID (two hybrid)

		STK39	OTOF
Description		serine/threonine kinase 39	otoferlin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cell Projection Presynaptic Active Zone Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Molecular_function Calcium Ion Binding AP-2 Adaptor Complex Binding
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Plasma Membrane Organization Sensory Perception Of Sound Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Membrane Fusion
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Fostamatinib
Diseases			Deafness, autosomal recessive
GWAS		Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)	Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Periodontal microbiota ( 22699663)
Interacting Genes		14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4	2 interacting genes: SRPK2 STK39
Entrez ID		27347	9381
HPRD ID		09627	04727
Ensembl ID		ENSG00000198648	ENSG00000115155
Uniprot IDs		Q9UEW8	Q9HC10
PDB IDs
Enriched GO Terms of Interacting Partners?
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