MED12 and CDK8

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)
HPRD (in vivo)

		MED12	CDK8
Description		mediator complex subunit 12	cyclin dependent kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex	Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Stem Cell Population Maintenance Spinal Cord Development Post-anal Tail Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs			Alvocidib
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Uterine fibroids ( 31649266)	Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)
Interacting Genes		16 interacting genes: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 NANOG PPARGC1A SOX9 SREBF1 VDR	38 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CTDP1 ERBB2 ERCC3 ESR1 ESR2 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		9968	1024
HPRD ID		02176	04422
Ensembl ID		ENSG00000184634	ENSG00000132964
Uniprot IDs		Q93074	P49336
PDB IDs			3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41
Enriched GO Terms of Interacting Partners?
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