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MED12 and NANOG
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
MED12
NANOG
Description
mediator complex subunit 12
Nanog homeobox
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Nuclear Receptor Coactivator Activity
Vitamin D Receptor Binding
Thyroid Hormone Receptor Binding
Ubiquitin Protein Ligase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Neural Tube Closure
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Endoderm Development
Heart Development
Oligodendrocyte Development
Schwann Cell Development
Protein Ubiquitination
Stem Cell Population Maintenance
Spinal Cord Development
Post-anal Tail Morphogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Neurocranium Morphogenesis
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Axis Elongation Involved In Somitogenesis
Embryonic Brain Development
Negative Regulation Of Transcription By RNA Polymerase II
Endodermal Cell Fate Specification
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Cell Differentiation
Somatic Stem Cell Population Maintenance
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Stem Cell Proliferation
Pathways
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
FG syndrome (FGS); Opitz-Kaveggia syndrome
MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome
GWAS
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Uterine fibroids (
31649266
)
Interacting Genes
16 interacting genes:
CDK8
ESR1
ESR2
GLI3
LYST
MED1
MED13
MED26
MED29
MED8
MED9
NANOG
PPARGC1A
SOX9
SREBF1
VDR
7 interacting genes:
BRAF
MED12
PRKCE
RBPMS
RHOXF2
SPOP
USP21
Entrez ID
9968
79923
HPRD ID
02176
06397
Ensembl ID
ENSG00000184634
ENSG00000111704
Uniprot IDs
Q93074
A8K4D1
Q9H9S0
PDB IDs
2KT0
4RBO
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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