MFN2 and MARCHF5

Data Source:
HPRD (in vitro, in vivo)

		MFN2	MARCHF5
Description		mitofusin 2	membrane associated ring-CH-type finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding	Protein Binding Zinc Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Mitochondrion Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Macroautophagy Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging
Pathways		PINK1-PRKN Mediated Mitophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494) Tuberculosis ( 29036319)
Interacting Genes		2 interacting genes: MARCHF5 PRKN	39 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 MANBAL MAP1B MFN2 ODF4 PTPN5 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A
Entrez ID		9927	54708
HPRD ID		08495	07909
Ensembl ID		ENSG00000116688	ENSG00000198060
Uniprot IDs		O95140	Q9NX47
PDB IDs		6JFK 6JFL 6JFM
Enriched GO Terms of Interacting Partners?
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