PAN2 and RNF144B

Data Source:
BioGRID (two hybrid)

		PAN2	RNF144B
Description		poly(A) specific ribonuclease subunit PAN2	ring finger protein 144B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol PAN Complex	Ubiquitin Ligase Complex Cytoplasm Cytosol Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Protein Phosphopantetheinylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process
Pathways		Deadenylation of mRNA	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 25429064) Refractive error ( 32231278)	Adult body size ( 32376654) Age at voice drop ( 27182965) Caudal middle frontal gyrus volume ( 31530798) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Facial morphology ( 31763980) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Dorea) ( 33208821) Pulse pressure ( 30224653) Thiopurine S-methyltransferase activity ( 27770449) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35	28 interacting genes: ANKS1A CDKN1A CHCHD2 CREB5 FOXH1 IL16 OTX1 PAN2 PAX5 PRKAB2 PROP1 PRR35 RIPPLY1 SGTA SGTB TRAF4 UBC UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z UBQLN1 USP15 USP2 VENTX ZIC1
Entrez ID		9924	255488
HPRD ID		15640	17126
Ensembl ID		ENSG00000135473	ENSG00000137393
Uniprot IDs		Q504Q3	Q7Z419
PDB IDs
Enriched GO Terms of Interacting Partners?
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