PAN2 and TRIM35

Data Source:
BioGRID (two hybrid)

		PAN2	TRIM35
Description		poly(A) specific ribonuclease subunit PAN2	tripartite motif containing 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol PAN Complex	Nucleus Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	Molecular_function Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Protein Phosphopantetheinylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		Deadenylation of mRNA	Interferon gamma signaling
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 25429064) Refractive error ( 32231278)	Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		7 interacting genes: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35	49 interacting genes: ADIPOQ BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410
Entrez ID		9924	23087
HPRD ID		15640	15553
Ensembl ID		ENSG00000135473	ENSG00000104228
Uniprot IDs		Q504Q3	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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