TBC1D4 and NAV1

Data Source:
HPRD (two hybrid)

		TBC1D4	NAV1
Description		TBC1 domain family member 4	neuron navigator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Vesicle	Cytoplasm Microtubule Microtubule Cytoskeleton Axon Initial Segment
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity	Microtubule Bundle Formation Neuron Migration Nervous System Development
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 25673413 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Calcific aortic valve stenosis ( 32141789) Celiac disease ( 23936387) Diastolic blood pressure ( 30578418) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Sleep duration (short sleep) ( 30846698) Waist circumference ( 25673412)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	10 interacting genes: APC APP DDIT4L GCC1 KIFAP3 KRT31 MAPRE1 PRIMPOL RSRC2 TBC1D4
Entrez ID		9882	89796
HPRD ID		18164	10113
Ensembl ID		ENSG00000136111	ENSG00000134369
Uniprot IDs		A0A3B3IRT3 O60343	Q8NEY1
PDB IDs		3QYB
Enriched GO Terms of Interacting Partners?
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