TBC1D4 and NFAT5

Data Source:
HPRD (two hybrid)

		TBC1D4	NFAT5
Description		TBC1 domain family member 4	nuclear factor of activated T cells 5
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GO Annotations	Cellular Component	Cytosol Vesicle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity	Cytokine Production Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Osmotic Stress Signal Transduction Excretion Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Adult body size ( 32376654) Blood osmolality (transformed sodium) ( 28360221) Blood urea nitrogen levels ( 31152163 29403010) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Chloride levels ( 29403010) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hyperuricemia ( 29124443) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Pulse pressure ( 28135244 27841878) Self-reported risk-taking behaviour ( 30181555) Serum uric acid levels ( 30993211 29124443) SjÃ¶gren's syndrome ( 28076899) Smoking initiation (ever regular vs never regular) ( 30679032) Sodium levels ( 29403010) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 30297969) Urate levels ( 31985003 23263486)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	3 interacting genes: FOXP3 TBC1D4 TRIM14
Entrez ID		9882	10725
HPRD ID		18164	05272
Ensembl ID		ENSG00000136111	ENSG00000102908
Uniprot IDs		A0A3B3IRT3 O60343	A0A024R734 O94916
PDB IDs		3QYB	1IMH
Enriched GO Terms of Interacting Partners?
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