TLK1 and DPPA4

Data Source:
BioGRID (two hybrid)

		TLK1	DPPA4
Description		tousled like kinase 1	developmental pluripotency associated 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Chromatin Binding Protein Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Multicellular Organism Development Somatic Stem Cell Population Maintenance System Development
Pathways			POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs		Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	35 interacting genes: BTBD2 CIR1 CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM
Entrez ID		9874	55211
HPRD ID		12232	16836
Ensembl ID		ENSG00000198586	ENSG00000121570
Uniprot IDs		Q9UKI8	Q7L190
PDB IDs
Enriched GO Terms of Interacting Partners?
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