TLK1 and ASF1A

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TLK1	ASF1A
Description		tousled like kinase 1	anti-silencing function 1A histone chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Osteoblast Differentiation DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Negative Regulation Of Chromatin Silencing Muscle Cell Differentiation
Pathways			Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)
Interacting Genes		28 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	35 interacting genes: ASF1B CDAN1 CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 NASP PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17
Entrez ID		9874	25842
HPRD ID		12232	16459
Ensembl ID		ENSG00000198586	ENSG00000111875
Uniprot IDs		Q9UKI8	Q9Y294
PDB IDs			1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H
Enriched GO Terms of Interacting Partners?
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