DPPA4 and PTPRO

Data Source:
BioGRID (two hybrid)

		DPPA4	PTPRO
Description		developmental pluripotency associated 4	protein tyrosine phosphatase receptor type O
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Chromatin Binding Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Multicellular Organism Development Somatic Stem Cell Population Maintenance System Development	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Signaling by NTRK3 (TRKC)
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)	Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)
Interacting Genes		35 interacting genes: BTBD2 CIR1 CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM	9 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ
Entrez ID		55211	5800
HPRD ID		16836	02784
Ensembl ID		ENSG00000121570	ENSG00000151490
Uniprot IDs		Q7L190	A0A024RAS0 A0A024RAS9 Q16827
PDB IDs			2G59 2GJT
Enriched GO Terms of Interacting Partners?
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