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ATN1 and CASP1
Data Source:
HPRD
(in vitro)
ATN1
CASP1
Description
atrophin 1
caspase 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Cell Junction
Perinuclear Region Of Cytoplasm
Extracellular Region
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Protein-containing Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Protein Domain Specific Binding
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Kinase Binding
Identical Protein Binding
CARD Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Central Nervous System Development
Neuron Apoptotic Process
Response To Hypoxia
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Regulation Of Autophagy
Protein Autoprocessing
Cytokine-mediated Signaling Pathway
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Alpha Production
Positive Regulation Of Interleukin-1 Beta Production
Response To ATP
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Inflammatory Response
Mitochondrial Depolarization
Membrane Hyperpolarization
Pyroptosis
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Cytokine Stimulus
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Programmed Necrotic Cell Death
Signaling Receptor Ligand Precursor Processing
Toxin Transport
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Regulation of PTEN gene transcription
NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
Dentatorubropallidoluysian atrophy (DRPLA)
GWAS
Refractive error (
32231278
)
Hip circumference adjusted for BMI (
28552196
)
Interacting Genes
121 interacting genes:
AGRN
ALG13
ARF3
ATRX
BAG3
BAG6
BAIAP2
CACNB1
CASP1
CASP3
CBFA2T2
CENPJ
CHRD
CRACR2A
CRIP2
CSNK2A1
CTNND2
DGCR6L
DMPK
DMRT3
DVL1
DVL2
ECM1
EFEMP1
EFEMP2
ETNK2
EWSR1
FBLN1
FBLN2
FBLN5
GAPDH
GCC1
GIGYF1
GRN
HGS
HINFP
HNRNPF
HSPG2
ITCH
JAG2
KAT6A
KAT6B
KAT7
KRT31
KRTAP12-2
KRTAP15-1
KRTAP19-2
KRTAP19-5
KRTAP4-12
KRTAP6-2
KRTAP9-3
LENG8
LRP2
LTBP1
LTBP4
LYST
MAGI1
MAGI2
MAP7D1
MBP
MDFI
MEGF11
MEGF6
MEGF8
NCK2
NELL1
NELL2
NOC2L
NR2E1
OLIG3
P4HA3
PCSK5
PDCD6IP
PFKL
PIN1
PITX1
PITX2
PLSCR1
PPP1R32
PRRC2A
PRRC2B
PSMA3
PSME3
RAD54L2
RBFOX1
RBFOX2
RBM10
RBM14
RBM4B
RBPMS
RCHY1
RERE
RHOXF2
RNF115
RNF31
RUNX1T1
SH3RF1
SIAH1
SIAH2
SLC25A48
SLIT1
SPAG5
SS18L1
SSPOP
STXBP4
SYVN1
TEKT3
TEP1
TLE1
TLE5
TNFAIP8
TRIP6
USP2
USP54
VIM
WDR5
WWP1
WWP2
ZMYND8
ZNF503
ZSWIM8
42 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
EGFR
FGF2
HTT
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
SERPINB9
TFAP2A
TIRAP
VAC14
Entrez ID
1822
834
HPRD ID
06311
00977
Ensembl ID
ENSG00000111676
ENSG00000137752
Uniprot IDs
P54259
Q86V38
A8K249
A8K257
P29466
PDB IDs
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
Enriched GO Terms of Interacting Partners
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