ELMO1 and FGD1

Data Source:
HPRD (in vivo)

		ELMO1	FGD1
Description		engulfment and cell motility 1	FYVE, RhoGEF and PH domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases			Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)	Prostate cancer ( 31562322)
Interacting Genes		10 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398	5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1
Entrez ID		9844	2245
HPRD ID		12102	02373
Ensembl ID		ENSG00000155849	ENSG00000102302
Uniprot IDs		A4D1X5 Q92556	A0A024R9Y5 P98174
PDB IDs		2RQR 2VSZ 3A98 6JPP 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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