ELMO1 and ADGRB3

Data Source:
BioGRID (two hybrid)

		ELMO1	ADGRB3
Description		engulfment and cell motility 1	adhesion G protein-coupled receptor B3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Synaptic Cleft Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	G Protein-coupled Receptor Activity GTPase Activator Activity Protein Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Myoblast Fusion Neuron Remodeling Negative Regulation Of Angiogenesis Positive Regulation Of GTPase Activity Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Motor Learning Maintenance Of Synapse Structure
Pathways		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)	General risk tolerance (MTAG) ( 30643258) Negative urgency ( 30718321) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		10 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398	8 interacting genes: C1QL3 ELMO1 GPATCH11 GPR37L1 MUC1 SLC7A1 SNTA1 TLCD4
Entrez ID		9844	577
HPRD ID		12102	04064
Ensembl ID		ENSG00000155849	ENSG00000135298
Uniprot IDs		A4D1X5 Q92556	O60242
PDB IDs		2RQR 2VSZ 3A98 6JPP 6TGB 6TGC	4DLO
Enriched GO Terms of Interacting Partners?
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