FGD1 and ELMO1

Data Source:
HPRD (in vivo)

		FGD1	ELMO1
Description		FYVE, RhoGEF and PH domain containing 1	engulfment and cell motility 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases		Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS		Prostate cancer ( 31562322)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)
Interacting Genes		5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1	10 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		2245	9844
HPRD ID		02373	12102
Ensembl ID		ENSG00000102302	ENSG00000155849
Uniprot IDs		A0A024R9Y5 P98174	A4D1X5 Q92556
PDB IDs			2RQR 2VSZ 3A98 6JPP 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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