FGD1 and AOC1

Data Source:
HPRD (in vitro, in vivo)

		FGD1	AOC1
Description		FYVE, RhoGEF and PH domain containing 1	amine oxidase copper containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Specific Granule Lumen Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Heparin Binding Zinc Ion Binding Protein Homodimerization Activity Protein-containing Complex Binding Quinone Binding Diamine Oxidase Activity Histamine Oxidase Activity Methylputrescine Oxidase Activity Propane-1,3-diamine Oxidase Activity
	Biological Process	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Xenobiotic Metabolic Process Amine Metabolic Process Putrescine Metabolic Process Cellular Response To Copper Ion Starvation Neutrophil Degranulation Response To Antibiotic Cellular Response To Copper Ion Cellular Response To Histamine Cellular Response To Heparin Cellular Response To Azide
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			Amiloride Calcium Diminazene
Diseases		Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS		Prostate cancer ( 31562322)	Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Carpal tunnel syndrome ( 30833571) Eyebrow thickness ( 26926045) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1	13 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10
Entrez ID		2245	26
HPRD ID		02373	00088
Ensembl ID		ENSG00000102302	ENSG00000002726
Uniprot IDs		A0A024R9Y5 P98174	P19801
PDB IDs			3HI7 3HIG 3HII 3K5T 3MPH
Enriched GO Terms of Interacting Partners?
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