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GOLGA2 and AXIN1
Data Source:
BioGRID
(two hybrid)
GOLGA2
AXIN1
Description
golgin A2
axin 1
Image
GO Annotations
Cellular Component
Golgi Cis Cisterna
Golgi Membrane
Spindle Pole
Golgi Apparatus
Cis-Golgi Network
Microtubule
COPII-coated ER To Golgi Transport Vesicle
Golgi Cisterna Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Mitotic Spindle
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Molecular Function
Protein Binding
Microtubule Binding
Protein Kinase Binding
Syntaxin Binding
Identical Protein Binding
Cadherin Binding
Importin-alpha Family Protein Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
Biological Process
Protein Glycosylation
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Microtubule Nucleation
Golgi Organization
Centrosome Cycle
Asymmetric Cell Division
Negative Regulation Of Autophagy
Protein Transport
Negative Regulation Of Protein Binding
COPII Vesicle Coating
Spindle Assembly
Protein Homotetramerization
Positive Regulation Of Protein Glycosylation
Golgi Ribbon Formation
Golgi Disassembly
Spindle Assembly Involved In Meiosis
Mitotic Spindle Assembly
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
COPII-mediated vesicle transport
COPI-mediated anterograde transport
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
1,4-Dithiothreitol
Diseases
Hepatocellular carcinoma
Caudal duplication anomaly
GWAS
Adult body size (
32376654
)
Body mass index (
26426971
)
Adult body size (
32376654
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
461 interacting genes:
ABHD17A
ABLIM1
ADAP1
AFF4
ALKBH2
ALKBH3
AMOTL2
ANKHD1
ANKRD11
ANKRD36
ANKRD36BP1
ANKS1A
APC
AQP1
ARFIP2
ARHGAP45
ARHGEF6
ARID5A
ARL16
ARL4A
ARNT2
ARPC3
ATP5PO
ATP6V1C2
ATP6V1D
ATP6V1G1
ATXN7
AXIN1
BAHD1
BARD1
BAZ2B
BCAS2
BCL6
BCL6B
BMS1P1
BYSL
C12orf50
C19orf44
C1orf109
C1orf35
C2CD6
CAB39
CAPN7
CBX8
CBY2
CCAR1
CCDC120
CCDC13
CCDC146
CCDC150
CCDC17
CCDC185
CCDC187
CCDC198
CCDC70
CCDC87
CCDC92
CCHCR1
CCNC
CCNH
CDC20B
CDC37
CDC5L
CDC7
CDC73
CDCA7L
CDK1
CDK18
CDKL3
CDKN1A
CENPP
CEP55
CEP57L1
CEP95
CHCHD2
CHCHD3
CIC
CINP
CKB
CLIP3
COG6
CORO1A
COX5B
CRACR2A
CRMP1
CSPP1
CSTF2T
CUL5
CWF19L2
CYB5R2
DAXX
DCTN4
DCX
DDX6
DEUP1
DGCR6
DLGAP3
DLGAP5
DLX6-AS1
DMTN
DNM2
DTX2
DVL2
EAF2
EFCAB6
EFHC1
EGR2
EIF3G
EIF4A2
ENKD1
ENPP7
EP300
ERCC3
ESCO2
EXOC8
EXOSC5
FAM110A
FAM124B
FAM126B
FAM161A
FAM161B
FAM184A
FAM193B
FAM207A
FAM214A
FAM214B
FAM50B
FAM90A1
FANCG
FBF1
FBXL18
FBXO28
FIP1L1
FNDC11
FOXC2
GADD45GIP1
GAS2L2
GAS8
GATA1
GATA2
GATAD2B
GCC1
GEM
GFAP
GGA2
GGN
GLYCTK
GMCL1
GNG5
GNL3L
GORASP1
GORASP2
GPANK1
GPKOW
GPS2
GRAP2
GRB14
GSE1
GTPBP10
GZMA
GZMK
HAUS1
HDAC4
HGS
HOXB5
HOXB9
HTRA1
HYLS1
IFT20
IFT27
IGFN1
IHO1
IKZF3
IL16
INPP5J
IQCE
IQUB
ISCU
ITGB5
ITPKB
ITSN2
KANK2
KANSL1
KAT5
KDM1A
KIAA1217
KIFC3
KRT1
KRT18
KRT6A
KRT6B
KRT6C
KRT75
L3MBTL2
LASP1
LATS1
LCOR
LCP2
LENG1
LGALS3
LHX4
LIMS2
LIN7A
LINGO1
LMNB2
LMO1
LMO2
LMO3
LMO4
LYPLA1
LYSMD1
MAB21L2
MAGOH
MAGOHB
MBD3
MCM10
MCM7
MCRS1
MFAP1
MID2
MISP
MNAT1
MORF4L1
MORF4L2
MORN3
MOS
MSRB3
MTFR2
MVP
MYEF2
NCF2
NDC80
NDE1
NDEL1
NDN
NDUFA5
NEBL
NECAB2
NEFL
NME7
NOS3
NOTCH1
NSMF
NTAQ1
NUDT21
NXT2
OAS1
ODAD4
ORC1
PACRGL
PARD6B
PATL1
PCM1
PIAS2
PIBF1
PID1
PIK3R2
PIMREG
PIN1
PITX1
PKN1
PKN3
PKP1
PKP2
PKP4
PLAAT5
PLEKHA2
POLDIP3
POLR3C
POM121
POU4F3
PPP1R16B
PPP1R18
PPP1R32
PPP2CA
PQBP1
PRAM1
PRKAA1
PRKAA2
PRKAB2
PRPF18
PRPF3
PRPF31
PSMA1
PSMA4
PTBP2
PTPN11
PTPN21
RAB1A
RAB1B
RAB2A
RAB2B
RAB33B
RAB39A
RAB39B
RAB6A
RAD18
RAMAC
RANBP3
RANBP3L
RBL1
RBM17
RBM22
RBM25
RBM39
RBM41
RCL1
RCOR3
RGS8
RHNO1
RHOJ
RHPN1
RIBC1
RIN1
RITA1
RNF135
RNF169
RNF213
RNF214
RNF6
RSPH14
RSRC2
RTP5
RUSC2
RXRB
SAMD4A
SAP30BP
SCAF8
SCEL
SCNM1
SECISBP2
SELENOV
SFI1
SH2D4A
SH3GLB2
SH3RF2
SHC3
SHISA6
SLU7
SMARCB1
SMARCE1
SMCP
SMG9
SNAP47
SNF8
SNRPB
SNRPB2
SNRPC
SNTA1
SNW1
SNX18
SORBS2
SPATA18
SPATA2
SPATA22
SPG21
SRSF2
SSX2IP
STAC
STAMBPL1
STK25
STK26
STN1
SUDS3
SUGP2
SUPT5H
SYNPO2L
SYT17
SYT6
TBC1D22B
TBC1D30
TBP
TCEA2
TCEANC
TCF19
TCL1A
TDP2
TEAD4
TEPSIN
TEX9
TFAP4
TFIP11
THAP7
THYN1
TLE5
TMED2
TPM1
TPRX1
TPX2
TRAF1
TRAF3IP2
TRAF4
TRAF5
TRIM14
TRIM29
TRIM42
TSC22D4
TSGA10
TSGA10IP
TSHZ2
TSHZ3
TSSC4
TSSK3
TTC23
TTC9C
TTPA
TUBGCP4
TXLNA
TXLNB
UBE2H
UBE2I
UBE2U
UBE3C
UBTFL1
USO1
USP15
USP2
UTP14C
UTP23
VPS28
VPS37C
WASHC3
WHRN
WT1
XIAP
YJU2
YTHDC1
ZBTB16
ZBTB4
ZBTB42
ZC2HC1C
ZFC3H1
ZFHX3
ZFP2
ZFYVE26
ZG16B
ZGPAT
ZMAT1
ZMAT2
ZNF124
ZNF250
ZNF280C
ZNF3
ZNF35
ZNF410
ZNF414
ZNF417
ZNF438
ZNF48
ZNF488
ZNF512B
ZNF524
ZNF572
ZNF581
ZNF587
ZNF594
ZNF648
ZNF688
ZNF774
ZNF835
ZZZ3
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
USP7
UTP14A
ZBTB26
ZFYVE19
Entrez ID
2801
8312
HPRD ID
03989
04819
Ensembl ID
ENSG00000167110
ENSG00000103126
Uniprot IDs
Q08379
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
4REY
6IW8
6IWA
6K06
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
Enriched GO Terms of Interacting Partners
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