CUL7 and UBE2M

Data Source:
BioGRID (enzymatic study)

		CUL7	UBE2M
Description		cullin 7	ubiquitin conjugating enzyme E2 M
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GO Annotations	Cellular Component	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		3M syndrome
GWAS			Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		9 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 UBE2M	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		9820	9040
HPRD ID		09901	04414
Ensembl ID		ENSG00000044090	ENSG00000130725
Uniprot IDs		Q14999	A0A024R4T4 P61081
PDB IDs		2JNG	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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