IP6K1 and COPS2

Data Source:
BioGRID (pull down)

		IP6K1	COPS2
Description		inositol hexakisphosphate kinase 1	COP9 signalosome subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Negative Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Synthesis of pyrophosphates in the cytosol Synthesis of IPs in the nucleus	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hand grip strength ( 29691431) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 29769521 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Ulcerative colitis ( 25082827)	Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		12 interacting genes: ADAMTSL4 CACNA1A CLK1 COPS2 DDB1 EXOSC7 GPS1 PICK1 RAB3IL1 RPL11 UBE4A VIM	38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446
Entrez ID		9807	9318
HPRD ID		07379	05146
Ensembl ID		ENSG00000176095	ENSG00000166200
Uniprot IDs		A0A024R2X2 Q92551	P61201 Q59EL2
PDB IDs			4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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