IP6K1 and EXOSC7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IP6K1	EXOSC7
Description		inositol hexakisphosphate kinase 1	exosome component 7
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Negative Regulation Of Cold-induced Thermogenesis	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways		Synthesis of pyrophosphates in the cytosol Synthesis of IPs in the nucleus	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hand grip strength ( 29691431) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 29769521 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Ulcerative colitis ( 25082827)	Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)
Interacting Genes		12 interacting genes: ADAMTSL4 CACNA1A CLK1 COPS2 DDB1 EXOSC7 GPS1 PICK1 RAB3IL1 RPL11 UBE4A VIM	18 interacting genes: APP DIS3 DXO ESRRG EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPHOSPH6 MTREX PALS2 PTEN UBE2K
Entrez ID		9807	23016
HPRD ID		07379	09401
Ensembl ID		ENSG00000176095	ENSG00000075914
Uniprot IDs		A0A024R2X2 Q92551	A0A024R2T3 B2RDZ9 Q15024
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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