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COPS2 and RXRA
Data Source:
HPRD
(two hybrid, in vitro)
COPS2
RXRA
Description
COP9 signalosome subunit 2
retinoid X receptor alpha
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
COP9 Signalosome
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
NEDD8-specific Protease Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Receptor Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Inner Cell Mass Cell Proliferation
Transcription-coupled Nucleotide-excision Repair
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Neuron Differentiation
Skeletal Muscle Cell Differentiation
Post-translational Protein Modification
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cholesterol Metabolic Process
Bile Acid And Bile Salt Transport
Modulation By Virus Of Host Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Anatomical Structure Development
Pathways
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine metabolism
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
Diseases
GWAS
Lung adenocarcinoma (
28604730
)
Lung cancer (
28604730
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
28171582
22814818
31798171
23493294
29760442
30894546
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Interacting Genes
38 interacting genes:
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS7B
COPS8
CSNK2A1
CUL5
DDB1
EP300
GFER
GPS1
H3C1
H4C1
ING1
ING2
IP6K1
IRF8
MAP3K10
MAPK8
NCOR1
NIF3L1
NR0B1
NR2F1
PRKD1
PSMD11
RARA
RND1
RXRA
SENP8
SIN3A
SIN3B
THRA
THRB
TP53
VDR
ZNF446
118 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
ARNTL
BCL3
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
VDR
ZBTB16
ZNHIT3
Entrez ID
9318
6256
HPRD ID
05146
01577
Ensembl ID
ENSG00000166200
ENSG00000186350
Uniprot IDs
P61201
Q59EL2
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
PDB IDs
4D10
4D18
4WSN
6A73
6R6H
6R7F
6R7H
6R7I
6R7N
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6SJM
6STI
6XWG
6XWH
7A77
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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