COPS2 and ING2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		COPS2	ING2
Description		COP9 signalosome subunit 2	inhibitor of growth family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Nucleus Nucleoplasm Plasma Membrane Sin3 Complex CCAAT-binding Factor Complex
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Phosphatidylinositol Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription	Chromatin Organization Regulation Of Transcription, DNA-templated Male Meiosis I Signal Transduction Spermatogenesis Spermatid Development Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Growth Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Seminiferous Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	SUMOylation of transcription cofactors PI5P Regulates TP53 Acetylation
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446	8 interacting genes: APP COPS2 EP300 H3-4 H4-16 SMAD1 SMURF1 SMURF2
Entrez ID		9318	3622
HPRD ID		05146	05021
Ensembl ID		ENSG00000166200	ENSG00000168556
Uniprot IDs		P61201 Q59EL2	B2RA15 Q9H160
PDB IDs		4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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