GPRASP1 and GRM8

Data Source:
HPRD (in vitro)

		GPRASP1	GRM8
Description		G protein-coupled receptor associated sorting protein 1	glutamate metabotropic receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Glutamic acid
Diseases
GWAS			Anti-saccade response ( 29064472 25387707) Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Depression (quantitative trait) ( 20800221) Experiencing mood swings ( 29500382) Fasting glucose change (long-term) ( 31263163) Feeling hurt ( 29500382) Feeling worry ( 29500382) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Neurociticism ( 29500382) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Smoking initiation ( 30617275) Type 2 diabetes ( 32499647) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		47 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2
Entrez ID		9737	2918
HPRD ID		02333	03071
Ensembl ID		ENSG00000198932	ENSG00000179603
Uniprot IDs		Q5JY77	O00222
PDB IDs			6BSZ 6BT5 6E5V
Enriched GO Terms of Interacting Partners?
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