GPRASP1 and CHRM4

Data Source:
HPRD (in vitro)

		GPRASP1	CHRM4
Description		G protein-coupled receptor associated sorting protein 1	cholinergic receptor muscarinic 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding	G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		47 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	20 interacting genes: B2M CBFA2T3 CD59 CD81 EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 MFSD4A QSOX1 RAB3A RHBDD2 RTN4 SMIM7 SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		9737	1132
HPRD ID		02333	00330
Ensembl ID		ENSG00000198932	ENSG00000180720
Uniprot IDs		Q5JY77	P08173
PDB IDs			5DSG 6D9H 6KP6
Enriched GO Terms of Interacting Partners?
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