DOCK4 and RNF115

Data Source:
BioGRID (two hybrid)

		DOCK4	RNF115
Description		dedicator of cytokinesis 4	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Cell Chemotaxis Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Factors involved in megakaryocyte development and platelet production	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index (change over time) ( 25378290) C-reactive protein and white blood cell count ( 22788528) Migraine ( 27322543) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Response to fenofibrate ( 22890011) Total intracranial volume ( 31530798)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		4 interacting genes: ELMO2 FASLG GRB2 RNF115	32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2
Entrez ID		9732	27246
HPRD ID		07407	18328
Ensembl ID		ENSG00000128512	ENSG00000265491
Uniprot IDs		Q8N1I0	Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?
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