RNF115 and MFAP4

Data Source:
BioGRID (two hybrid)

		RNF115	MFAP4
Description		ring finger protein 115	microfibril associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Microfibril Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Elastic Fiber
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Antigen Binding Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Derivative Binding
	Biological Process	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Complement Activation, Lectin Pathway Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)	Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	2 interacting genes: RNF115 SFTPD
Entrez ID		27246	4239
HPRD ID		18328	02789
Ensembl ID		ENSG00000265491	ENSG00000166482
Uniprot IDs		Q9Y4L5	A0A024QZ34 P55083
PDB IDs
Enriched GO Terms of Interacting Partners?
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