RNF115 and FOLR3

Data Source:
BioGRID (two hybrid)

		RNF115	FOLR3
Description		ring finger protein 115	folate receptor gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Membrane Extrinsic Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Folic Acid Binding Signaling Receptor Activity
	Biological Process	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Sperm-egg Recognition Neutrophil Degranulation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs			Folic acid Vintafolide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)	Blood protein levels ( 29875488)
Interacting Genes		32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	3 interacting genes: ANKRD11 RNF115 UBQLN1
Entrez ID		27246	2352
HPRD ID		18328	03918
Ensembl ID		ENSG00000265491	ENSG00000110203
Uniprot IDs		Q9Y4L5	P41439
PDB IDs
Enriched GO Terms of Interacting Partners?
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