CD63 and PI4K2A

Data Source:
HPRD (in vivo)

		CD63	PI4K2A
Description		CD63 molecule	phosphatidylinositol 4-kinase type 2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Multivesicular Body Membrane Azurophil Granule Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Multivesicular Body, Internal Vesicle	Mitochondrion Lysosomal Membrane Endosome Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft
	Molecular Function	Protein Binding	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding
	Biological Process	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Protein Transport Cell Migration Cellular Protein Localization Endosome To Melanosome Transport Neutrophil Degranulation Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphorylation
Pathways		Platelet degranulation Neutrophil degranulation	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: AP4M1 CD82 CD9 F2RL1 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SLC22A1 SLC22A2 SRF TIMP1 TMEM80 VKORC1	6 interacting genes: APP CD63 ECSIT HRAS NOS3 RAD23A
Entrez ID		967	55361
HPRD ID		01121	11431
Ensembl ID		ENSG00000135404	ENSG00000155252
Uniprot IDs		A0A024RB05 P08962	Q9BTU6
PDB IDs			4HND 4HNE 4PLA 4YC4 5EUT 5I0N
Enriched GO Terms of Interacting Partners?
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