RALGPS1 and CEP76

Data Source:
BioGRID (two hybrid)

		RALGPS1	CEP76
Description		Ral GEF with PH domain and SH3 binding motif 1	centrosomal protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane	Centrosome Centriole Cytosol Protein-containing Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Ral Protein Signal Transduction Intracellular Signal Transduction Regulation Of Catalytic Activity	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Intraocular pressure ( 29617998 29785010 31959993) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 30285260)
Interacting Genes		5 interacting genes: APP C2orf88 CEP76 GRB2 RALA	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIR1 COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HSF2 HSPB7 ILVBL IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		9649	79959
HPRD ID		11479	12694
Ensembl ID		ENSG00000136828	ENSG00000101624
Uniprot IDs		Q5JS13	B4DP81 Q8TAP6
PDB IDs		3QXL
Enriched GO Terms of Interacting Partners?
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