CEP76 and PLA2G6

Data Source:
BioGRID (two hybrid)

		CEP76	PLA2G6
Description		centrosomal protein 76	phospholipase A2 group VI
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Protein-containing Complex	Extracellular Space Mitochondrion Cytosol Plasma Membrane Integral Component Of Membrane Pseudopodium Centriolar Satellite
	Molecular Function	Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Palmitoyl-CoA Hydrolase Activity Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine) Myristoyl-CoA Hydrolase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking	Chemotaxis Antibacterial Humoral Response Cardiolipin Biosynthetic Process Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs			Quinacrine
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS			Apolipoprotein A1 levels ( 32203549) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549 28334899 32154731) Triglycerides ( 24097068 20686565)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIR1 COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HSF2 HSPB7 ILVBL IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42
Entrez ID		79959	8398
HPRD ID		12694	04675
Ensembl ID		ENSG00000101624	ENSG00000184381
Uniprot IDs		B4DP81 Q8TAP6	O60733
PDB IDs
Enriched GO Terms of Interacting Partners?
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