HOMER2 and KPNA2

Data Source:
BioGRID (two hybrid)

		HOMER2	KPNA2
Description		homer scaffold protein 2	karyopherin subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Stereocilium Tip Neuronal Cell Body Intracellular Organelle Apical Part Of Cell Glutamatergic Synapse	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Host Cell Extrinsic Component Of Postsynaptic Specialization Membrane Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Protein Domain Specific Binding Synaptic Receptor Adaptor Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity
	Biological Process	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Viral Life Cycle
Pathways		Neurexins and neuroligins Neurexins and neuroligins	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)	Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		14 interacting genes: ABI3 AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PALLD PJA1 RYR1 SMURF1 UBXN1 VKORC1	109 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		9455	3838
HPRD ID		07269	02818
Ensembl ID		ENSG00000103942	ENSG00000182481
Uniprot IDs		Q9NSB8	P52292
PDB IDs			1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43
Enriched GO Terms of Interacting Partners?
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