CD27 and CD70

Data Source:
HPRD (in vivo)

		CD27	CD70
Description		CD27 molecule	CD70 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protease Binding Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	T Cell Mediated Immunity Signal Transduction Cell-cell Signaling B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Extrinsic Apoptotic Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Crohn's disease ( 26192919)	Asthma ( 32296059)
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	2 interacting genes: CD27 ELOVL4
Entrez ID		939	970
HPRD ID		01723	18515
Ensembl ID		ENSG00000139193	ENSG00000125726
Uniprot IDs		P26842	A0A0U5JA32 P32970
PDB IDs		5TL5 5TLJ 5TLK
Enriched GO Terms of Interacting Partners?
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