CD27 and UHRF2

Data Source:
BioGRID (far western blotting)

		CD27	UHRF2
Description		CD27 molecule	ubiquitin like with PHD and ring finger domains 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Histone Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Cell Cycle Maintenance Of DNA Methylation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest
Pathways		TNFs bind their physiological receptors	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Crohn's disease ( 26192919)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	38 interacting genes: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 YY1 ZNF410 ZNF618
Entrez ID		939	115426
HPRD ID		01723	18257
Ensembl ID		ENSG00000139193	ENSG00000147854
Uniprot IDs		P26842	Q96PU4
PDB IDs		5TL5 5TLJ 5TLK	1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO
Enriched GO Terms of Interacting Partners?
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