UHRF2 and UBE2W

Data Source:
BioGRID (two hybrid)

		UHRF2	UBE2W
Description		ubiquitin like with PHD and ring finger domains 2	ubiquitin conjugating enzyme E2 W
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Histone Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cell Cycle Maintenance Of DNA Methylation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways		SUMOylation of transcription cofactors	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)	Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)
Interacting Genes		38 interacting genes: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 YY1 ZNF410 ZNF618	78 interacting genes: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		115426	55284
HPRD ID		18257	07724
Ensembl ID		ENSG00000147854	ENSG00000104343
Uniprot IDs		Q96PU4	Q96B02 Q96FI0 X6REH9
PDB IDs		1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO	2A7L 2MT6
Enriched GO Terms of Interacting Partners?
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