ARHGAP18 and MPHOSPH6

Data Source:
HPRD (two hybrid)

		ARHGAP18	MPHOSPH6
Description		Rho GTPase activating protein 18	M-phase phosphoprotein 6
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	GTPase Activator Activity Cadherin Binding	RNA Binding Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility	Maturation Of 5.8S RRNA RRNA Processing
Pathways		Rho GTPase cycle	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)	Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		2 interacting genes: MPHOSPH6 PALS2	32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		93663	10200
HPRD ID		12474	16111
Ensembl ID		ENSG00000146376	ENSG00000135698
Uniprot IDs		Q8N392	H3BNT4 Q99547
PDB IDs			6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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