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CD9 and HBEGF
Data Source:
HPRD
(in vivo, two hybrid)
CD9
HBEGF
Description
CD9 molecule
heparin binding EGF like growth factor
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Extracellular Exosome
Extracellular Vesicle
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Clathrin-coated Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
Integrin Binding
Protein Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Biological Process
Platelet Degranulation
Cell Adhesion
Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization
Glial Cell Migration
Myoblast Fusion Involved In Skeletal Muscle Regeneration
Platelet Activation
Paranodal Junction Assembly
Receptor Internalization
Sperm-egg Recognition
Negative Regulation Of Cellular Component Movement
Cellular Response To Low-density Lipoprotein Particle Stimulus
Negative Regulation Of Platelet Aggregation
MAPK Cascade
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Muscle Organ Development
Regulation Of Heart Contraction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Wound Healing, Spreading Of Epidermal Cells
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Elastin Biosynthetic Process
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Membrane Organization
Positive Regulation Of Wound Healing
Regulation Of Cell Motility
Pathways
Platelet degranulation
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Uptake and function of diphtheria toxin
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Uptake and function of diphtheria toxin
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
C31G
Diseases
GWAS
Colorectal cancer (
24836286
)
Colorectal cancer or advanced adenoma (
30510241
)
Mean platelet volume (
22139419
32888494
27863252
)
Paclitaxel-induced neuropathy (
23776197
)
Platelet count (
26805783
22139419
)
Alzheimer's disease (
28183528
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Atrial fibrillation (
28416822
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Creatine kinase levels (
29403010
)
General cognitive ability (
29844566
)
Intelligence (MTAG) (
29326435
)
White matter integrity (fractional anisotropy) (
32358547
)
White matter integrity (mean diffusivity) (
32358547
)
Interacting Genes
25 interacting genes:
ADAM2
ADRB2
CD19
CD36
CD38
CD53
CD59
CD63
CD81
CLN8
HBEGF
IGSF8
ITGA2
ITGA3
ITGA5
ITGB1
KIT
ODF4
PRKCA
PTGFRN
SERPINH1
SLC22A1
SLC22A2
TSPAN4
VKORC1
11 interacting genes:
BAG1
CD44
CD82
CD9
EGFR
ERBB4
FBLN1
LTBP3
MMP7
NRDC
ZBTB16
Entrez ID
928
1839
HPRD ID
00880
00526
Ensembl ID
ENSG00000010278
ENSG00000113070
Uniprot IDs
A6NNI4
B4DK09
P21926
Q99075
PDB IDs
6K4J
6RLR
6Z1V
6Z20
1XDT
2M8S
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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