HBEGF and LTBP3

Data Source:
HPRD (two hybrid)

		HBEGF	LTBP3
Description		heparin binding EGF like growth factor	latent transforming growth factor beta binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding	Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	MAPK Cascade Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Membrane Organization Positive Regulation Of Wound Healing Regulation Of Cell Motility	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Elastic Fiber Assembly Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Molecules associated with elastic fibres
Drugs
Diseases			Tooth agenesis; Hypodontia
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416822) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Creatine kinase levels ( 29403010) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) White matter integrity (fractional anisotropy) ( 32358547) White matter integrity (mean diffusivity) ( 32358547)	Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Refractive error ( 32231278) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	12 interacting genes: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3
Entrez ID		1839	4054
HPRD ID		00526	03649
Ensembl ID		ENSG00000113070	ENSG00000168056
Uniprot IDs		Q99075	B9EG76 Q8WYU6 Q9NS15
PDB IDs		1XDT 2M8S
Enriched GO Terms of Interacting Partners?
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