HBEGF and CD82

Data Source:
HPRD (in vivo)

		HBEGF	CD82
Description		heparin binding EGF like growth factor	CD82 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding	Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Membrane Organization Positive Regulation Of Wound Healing Regulation Of Cell Motility
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416822) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Creatine kinase levels ( 29403010) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) White matter integrity (fractional anisotropy) ( 32358547) White matter integrity (mean diffusivity) ( 32358547)	Blond vs. brown/black hair color ( 30531825) Cadmium levels ( 26025379) Hemostatic factors and hematological phenotypes ( 22443383) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Male-pattern baldness ( 27182965) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		11 interacting genes: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	27 interacting genes: BDKRB2 CANX CD19 CD4 CD63 CHRM5 CREB3 EGFR ERBB2 ERBB3 FFAR2 HBEGF HLA-DMA HLA-DMB HLA-DRA IGSF8 ITGA3 ITGA4 ITGA6 ITGB1 ITGB2 KLRC1 LRP1 NUP88 PTGFRN SMIM3 VANGL1
Entrez ID		1839	3732
HPRD ID		00526	09004
Ensembl ID		ENSG00000113070	ENSG00000085117
Uniprot IDs		Q99075	P27701
PDB IDs		1XDT 2M8S
Enriched GO Terms of Interacting Partners?
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