PAWR and SPSB4

Data Source:
BioGRID (unspecified method)

		PAWR	SPSB4
Description		pro-apoptotic WT1 regulator	splA/ryanodine receptor domain and SOCS box containing 4
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Positive Regulation Of Protein Polyubiquitination
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)	Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Stroke (ischemic) ( 23041239)
Interacting Genes		16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	3 interacting genes: DDX4 NOS2 PAWR
Entrez ID		5074	92369
HPRD ID		09051	18108
Ensembl ID		ENSG00000177425	ENSG00000175093
Uniprot IDs		Q96IZ0	Q96A44
PDB IDs		2JK9	2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?
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