PAWR and AATF

Data Source:
HPRD (in vivo)

		PAWR	AATF
Description		pro-apoptotic WT1 regulator	apoptosis antagonizing transcription factor
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Golgi Apparatus
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	RNA Binding Protein Binding Protein Kinase Binding Leucine Zipper Domain Binding Tau Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Embryonic Cleavage Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways			NRAGE signals death through JNK
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)	Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)
Interacting Genes		16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	28 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 NEDD4L NGDN PALS2 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		5074	26574
HPRD ID		09051	12236
Ensembl ID		ENSG00000177425	ENSG00000275700
Uniprot IDs		Q96IZ0	Q9NY61
PDB IDs		2JK9	5W6A
Enriched GO Terms of Interacting Partners?
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