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CRB3 and HMOX1
Data Source:
BioGRID
(two hybrid)
CRB3
HMOX1
Description
crumbs cell polarity complex component 3
heme oxygenase 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Bicellular Tight Junction
Integral Component Of Membrane
Apical Plasma Membrane
Cell Junction
Protein-containing Complex
Extracellular Exosome
Extracellular Space
Nucleus
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Caveola
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
SH3 Domain Binding
Protein Domain Specific Binding
Heme Oxygenase (decyclizing) Activity
Phospholipase D Activity
Structural Molecule Activity
Protein Binding
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Positive Regulation Of Cell Junction Assembly
Angiogenesis
Endothelial Cell Proliferation
Wound Healing Involved In Inflammatory Response
Negative Regulation Of Leukocyte Migration
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Excretion
Regulation Of Blood Pressure
Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Muscle Cell Apoptotic Process
Smooth Muscle Hyperplasia
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
Cellular Response To Nutrient
Positive Regulation Of Chemokine Production
Negative Regulation Of Mast Cell Cytokine Production
Erythrocyte Homeostasis
Low-density Lipoprotein Particle Clearance
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron
Cellular Response To Heat
Response To Nicotine
Intracellular Signal Transduction
Heme Catabolic Process
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Response To Estrogen
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Iron Ion Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Cadmium Ion
Cellular Response To Hypoxia
Cellular Response To Cisplatin
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Liver Regeneration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Tight junction interactions
Heme degradation
Interleukin-4 and Interleukin-13 signaling
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
NADH
Formic acid
Biliverdine IX Alpha
12-Phenylheme
2-Phenylheme
Verdoheme
Stannsoporfin
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS
Hippocampal volume in mild cognitive impairment (
29274321
)
Obesity-related traits (
23251661
)
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (
29748315
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
28 interacting genes:
ANKRD46
BCL2L13
BET1
FUNDC2
HMOX1
HMOX2
NDUFA3
PALS1
PARD6A
PATJ
PLLP
PLP2
PSENEN
PSMA3
RABAC1
SERF1A
SERF1B
SERP1
SLC39A9
STX5
TECR
TMEM222
TREX1
UBIAD1
VAMP1
VTI1B
WDR83
YIPF6
40 interacting genes:
AKT1
AQP6
ARL13B
ASL
BLVRB
CD79A
COQ9
CPLX4
CPSF1
CRB3
CREB3
CYB561
CYBRD1
ELOVL4
ELOVL5
ELOVL6
ERGIC3
FAM174A
FAM209A
FAM210B
GPR152
JAGN1
KASH5
LMNA
MSMO1
NOS1
PDZK1IP1
POR
POT1
PTGER4
SEC11C
SLC16A7
SMO
STX1A
TERF1
TLCD4
TM4SF19
TMEM14B
TMIE
TUT1
Entrez ID
92359
3162
HPRD ID
16749
00782
Ensembl ID
ENSG00000130545
ENSG00000100292
Uniprot IDs
Q9BUF7
P09601
Q6FH11
PDB IDs
5I7Z
1N3U
1N45
1NI6
1OYK
1OYL
1OZE
1OZL
1OZR
1OZW
1S13
1S8C
1T5P
1TWN
1TWR
1XJZ
1XK0
1XK1
1XK2
1XK3
3CZY
3HOK
3K4F
3TGM
4WD4
5BTQ
6EHA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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