LRRFIP1 and SERPINB5

Data Source:
BioGRID (two hybrid)

		LRRFIP1	SERPINB5
Description		LRR binding FLII interacting protein 1	serpin family B member 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Extracellular Space Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways		Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease
Drugs			S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Adiposity ( 23505185) Apolipoprotein A1 levels ( 32203549) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 30294719)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		6 interacting genes: CEP44 FBXO7 FLII MED4 SERPINB5 SH2D2A	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3
Entrez ID		9208	5268
HPRD ID		04460	01111
Ensembl ID		ENSG00000124831	ENSG00000206075
Uniprot IDs		A0A0F7NGI8 B4DPC0 Q32MZ4	A0A024R2B6 P36952
PDB IDs		4H22	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?
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