NODAL and ACVR2B

Data Source:
BioGRID (pull down)

		NODAL	ACVR2B
Description		nodal growth differentiation factor	activin A receptor type 2B
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GO Annotations	Cellular Component	Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Type I Activin Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Brain Development Embryonic Pattern Specification Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion BMP Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Floor Plate Morphogenesis Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Involved In Anterior/posterior Axis Specification Positive Regulation Of ERK1 And ERK2 Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Primitive Streak Formation Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by NODAL Regulation of signaling by NODAL	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases		Heterotaxy; Situs ambiguus	Heterotaxy; Situs ambiguus
GWAS			Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		6 interacting genes: ACVR1B ACVR2A ACVR2B KRT31 KRTAP6-3 TDGF1	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		4838	93
HPRD ID		08370	04106
Ensembl ID		ENSG00000156574	ENSG00000114739
Uniprot IDs		Q96S42	Q13705
PDB IDs		4N1D	2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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