ENG and TGFBR3

Data Source:
HPRD (in vivo)

		ENG	TGFBR3
Description		endoglin	transforming growth factor beta receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle	Extracellular Space Cytoplasm Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Response To Drug Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Angiogenesis Vasculogenesis Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs		Carotuximab
Diseases		Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148)	Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 26635082 30804560) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		13 interacting genes: ACVR1 ACVR2A BMP2 BMP7 DYNLT4 GDF2 INHBA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3	13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2
Entrez ID		2022	7049
HPRD ID		00565	02846
Ensembl ID		ENSG00000106991	ENSG00000069702
Uniprot IDs		A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0	A0A0A8KWK3 Q03167
PDB IDs		5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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