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ARHGEF2 and PAK1
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro)
ARHGEF2
PAK1
Description
Rho/Rac guanine nucleotide exchange factor 2
p21 (RAC1) activated kinase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Spindle
Cytosol
Cytoskeleton
Microtubule
Bicellular Tight Junction
Focal Adhesion
Cytoplasmic Vesicle
Vesicle
Ruffle Membrane
Protein-containing Complex
Ruffle
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Microtubule Binding
Transcription Factor Binding
Zinc Ion Binding
Small GTPase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Small GTPase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Cell Morphogenesis
Intracellular Protein Transport
Actin Filament Organization
Negative Regulation Of Microtubule Depolymerization
Cell Cycle
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Catalytic Activity
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Asymmetric Neuroblast Division
Negative Regulation Of Necroptotic Process
Cellular Response To Muramyl Dipeptide
Cellular Response To Tumor Necrosis Factor
Cellular Hyperosmotic Response
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Neuron Migration
MAPK Cascade
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Protein Phosphorylation
Exocytosis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Positive Regulation Of Cell Migration
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Microtubule Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Activation Of Protein Kinase Activity
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (age of onset) (
22959728
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body size at age 10 (
32376654
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Neuritic plaque (
31497858
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Interacting Genes
13 interacting genes:
CGN
MARK3
NFKBID
PAK1
PTPRF
RAC1
RHOA
RPP25L
RRAS2
YWHAE
YWHAG
YWHAQ
YWHAZ
85 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
Entrez ID
9181
5058
HPRD ID
10458
03995
Ensembl ID
ENSG00000116584
ENSG00000149269
Uniprot IDs
A0A5F9ZI21
Q92974
A0A024R5P0
Q13153
PDB IDs
5EFX
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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