DDIT3 and LMO2

Data Source:
BioGRID (two hybrid)

		DDIT3	LMO2
Description		DNA damage inducible transcript 3	LIM domain only 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex	Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Heterodimerization Activity Transcription Regulator Inhibitor Activity	RNA Polymerase II Activating Transcription Factor Binding Transcription Coregulator Binding Transcription Coactivator Activity Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Cell Cycle Arrest Sensory Perception Of Sound Anterior/posterior Axis Specification Regulation Of Autophagy Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of CREB Transcription Factor Activity Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Myxoid liposarcoma	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Brain morphology (MOSTest) ( 32665545)	Cognitive performance ( 19734545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252)
Interacting Genes		68 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CCDC153 CDK6 CEBPA CEBPB CEBPE CEBPG CRACR2A CREB3 CREB3L1 CREBL2 CSNK2A1 DBP DGCR2 DNMT3L EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIMAP6 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JDP2 JUN JUNB JUND KPNA2 LMO2 LNX1 MAFF MAFG MAPK14 MCMBP NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 TXN2 TXNDC2 VPS37C ZBTB25 ZC3H14 ZSCAN31	188 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 ARHGEF5 ARID5A ARNT2 AXIN1 BANP BCAS2 BEX2 BLZF1 BYSL C1orf109 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DMRT3 DRAP1 DYDC1 EFHC1 EFHC2 EHMT2 EIF3B EIF4EBP1 ELF2 ENKD1 ERBIN FAAP20 FAM214B FAM228A FAM90A1 FHL3 FHL5 GAS8 GATA1 GATA2 GATA3 GFAP GMEB2 GOLGA2 GRB2 HDAC5 HNRNPC HNRNPM HOOK1 ICA1L IFT43 IHO1 IKZF1 IKZF3 INCA1 ISL1 ISY1 KANK2 KAZN KDM5A KIF2A KIF3B KPRP KRT15 KRT34 KRT40 KRT75 KRT80 KRTAP10-7 LDB1 LDB2 LDOC1 LMO4 LMOD3 LYL1 LZTS1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MISP MRFAP1L1 MSN MTUS2 MYOZ3 N4BP2L2 NCAPH2 NDOR1 NDUFAB1 NDUFB7 NFKBID NHLH1 NIF3L1 NOTCH2NLA NOXA1 NSMF NTAQ1 NUP62 NUTM1 PATZ1 PAX9 PBX4 PDE9A PHC2 POLR2G PPP1R32 PRDM6 PRKG1 PSMA1 RBBP8 RCN1 REL RELA RINT1 RLIM ROCK1 RTL8C RUSC1 SAXO1 SGTB SKP1 SMAD2 SMUG1 SNAPC5 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TBX2 TCP10L TEKT3 TFIP11 TFPT THAP6 TLE5 TLX3 TRIB3 TRIM23 TRIM54 TRIM55 TRIM63 TRIP6 TSC1 TSC22D4 TSEN15 TSEN54 TSGA10IP TSPYL2 TSSK3 TUFT1 UBA6 UBASH3B UBE2I USH1G VBP1 VEZF1 VMAC WASF1 WASHC1 YOD1 YPEL3 ZFP64 ZMYND12 ZNF185 ZNF19 ZNF24 ZNF250 ZNF34 ZNF410 ZNF641 ZNF655 ZNF688
Entrez ID		1649	4005
HPRD ID		00529	01586
Ensembl ID		ENSG00000175197	ENSG00000135363
Uniprot IDs		P35638 Q53YD1	P25791
PDB IDs			2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?