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USP2 and AURKA
Data Source:
BioGRID
(enzymatic study)
USP2
AURKA
Description
ubiquitin specific peptidase 2
aurora kinase A
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Membrane
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Centrosome
Centriole
Spindle
Cytosol
Spindle Microtubule
Cilium
Microtubule Cytoskeleton
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Germinal Vesicle
Axon Hillock
Pronucleus
Perinuclear Region Of Cytoplasm
Spindle Midzone
Meiotic Spindle
Mitotic Spindle Pole
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Serine Kinase Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Muscle Organ Development
Protein Deubiquitination
Protein Phosphopantetheinylation
Circadian Regulation Of Gene Expression
Entrainment Of Circadian Clock By Photoperiod
Locomotor Rhythm
Positive Regulation Of Mitotic Cell Cycle
Circadian Behavior
Protein Stabilization
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spindle Organization
Mitotic Spindle Organization
Spindle Assembly Involved In Female Meiosis I
Mitotic Centrosome Separation
Response To Wounding
Anterior/posterior Axis Specification
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Histone-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Mitotic Nuclear Division
Regulation Of Centrosome Cycle
Protein Autophosphorylation
Cell Division
Centrosome Localization
Protein Localization To Centrosome
Liver Regeneration
Positive Regulation Of Oocyte Maturation
Regulation Of Signal Transduction By P53 Class Mediator
Neuron Projection Extension
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Regulation of TP53 Degradation
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA replication proteins
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA
Drugs
Phosphonothreonine
AT9283
CYC116
Alisertib
SNS-314
Cenisertib
Enzastaurin
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
AKI-001
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
2-(1H-pyrazol-3-yl)-1H-benzimidazole
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Fostamatinib
MLN8054
Diseases
GWAS
Refractive error (
32231278
)
Serum uric acid levels (
30993211
)
Urate levels (
31985003
31578528
23263486
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
163 interacting genes:
ABI2
ACTN1
ACTN2
ACTN3
APP
ASPG
ATN1
AURKA
BAP1
BCAR1
BCL2L2-PABPN1
BEGAIN
BEND5
BHLHB9
BICD2
BIRC7
BRCA1
CADPS
CALCOCO2
CARD9
CBLC
CCDC136
CCDC57
CCDC85B
CCDC88B
CCND1
CEP63
CEP70
CRACR2A
CRACR2B
CRY1
CTNNB1
DDI1
DEPDC5
DISC1
DTX3
DUSP21
DYDC1
EFHC2
EIF4ENIF1
ENPP1
ERBB2
EXOC5
EXOSC8
GEMIN4
GOLGA2
GOLGA6A
GOLGA6L9
GRB7
GRIPAP1
H2AC20
HOMER3
HOOK1
HOOK2
IHO1
IKBKG
IKZF3
IL1RL2
INTS11
JAKMIP1
JRK
KAZN
KIFC3
KRT15
KRT27
KRT31
KRT33B
KRT34
KRT35
KRT40
LHX3
LHX4
LMNA
LMNB2
LNX2
LONRF1
LRSAM1
LZTS2
MALT1
MAP3K2
MDM2
MID2
MNAT1
MORN5
MRPL28
MTUS2
MYC
NAB2
NDEL1
NEFL
NFKB2
NOTCH1
OIP5
OPTN
ORC3
ORC5
PALB2
PCGF6
PCNA
PEX5
PIBF1
PICK1
PIK3R3
PLA2G2A
PLEKHG4
PNMA1
POU2AF1
PRDM14
PRR5L
RABEP1
RAD18
RBCK1
RFX6
RNF125
RNF126
RNF144B
RNF166
RUNDC3A
S100A10
SH2B2
SNCA
SORBS3
SPAG8
SPDYE4
STAT5B
TAX1BP1
TEKT4
TFIP11
TGFBR1
TLE5
TNFAIP2
TRAF1
TRAF2
TRAF6
TRAIP
TRIM21
TRIM23
TRIM27
TRIM34
TRIM35
TRIM39
TRIM46
TRIM5
TRIM50
TRIM54
TRIM63
TRIM74
TRIM8
TRIM9
TRIP6
UBE2S
UBOX5
USHBP1
USP15
USP21
USP54
VCAM1
VPS28
VPS52
ZAP70
ZBED1
ZIM2
ZRANB1
170 interacting genes:
AATF
AKT1
ANGPTL4
ANP32B
APP
ARPC1B
ARPC2
ATRX
AUNIP
AURKAIP1
BAAT
BCL2L1
BEX2
BIRC5
BLID
BORA
BRAF
BRCA1
BTK
CBX3
CCND2
CCNE1
CDC20
CDC25B
CDH13
CDK8
CHFR
CKAP5
CORO2A
CSN2
CTCFL
CYLC2
DACH1
DKK3
EHMT2
EPHA2
EPSTI1
ERBB2
ERRFI1
FANCA
FBP2
FOXF1
FOXP1
FZR1
GADD45A
GMNN
GSK3B
GTF3C4
H3-4
H3C1
HDAC2
HDAC6
HEMGN
HIF1A
HNRNPF
HNRNPK
IFI16
IGFBP3
IKBKB
INCENP
KIF11
KIF2C
KLHL18
KLK5
LATS2
LEF1
LYPD3
MAP2K1
MAP2K3
MAP3K5
MAPK3
MAPRE2
MAPRE3
MBD3
MBP
MDM2
MED26
MTA3
MYC
MYT1
MYT1L
NANS
NAT2
NDC80
NEDD9
NF2
NFKBIA
NFXL1
NIN
NKX1-1
NME1
NSD2
NUF2
OTUB1
OTUD7B
PARP10
PAX4
PAX8
PDGFRA
PDLIM2
PLK3
PML
POU4F3
PPP1CA
PPP1CB
PPP1CC
PPP2CB
PPP3R2
PRKACA
PSEN2
PSMC3IP
PTPRD
PTTG1
PUM2
RASA1
RASSF1
RELA
REST
S100A14
SCGB3A1
SEC61B
SFRP4
SIN3B
SOX18
SOX3
SOX30
SOX4
SREBF2
SRPK1
SRPK2
SSRP1
STAT2
STK11
STX17
SUPT20H
SWT1
TACC1
TACC3
TBC1D2
TBX10
TCEAL2
TCERG1
TCF3
TEAD2
TFAP2B
TGFB1
THRSP
TLK1
TLK2
TP53
TP73
TPX2
TRMO
TRRAP
TSC1
TSTD2
UBE2C
UBE2I
UBE2N
UBTF
USP2
USP21
VHL
WIF1
XPA
YY1
ZFHX3
ZKSCAN2
ZNF189
ZNF510
Entrez ID
9099
6790
HPRD ID
05287
04066
Ensembl ID
ENSG00000036672
ENSG00000087586
Uniprot IDs
O75604
O14965
PDB IDs
2HD5
2IBI
3NHE
3V6C
3V6E
5XU8
5XVE
6DGF
1MQ4
1MUO
1OL5
1OL6
1OL7
2BMC
2C6D
2C6E
2DWB
2J4Z
2J50
2NP8
2W1C
2W1D
2W1E
2W1F
2W1G
2WQE
2WTV
2WTW
2X6D
2X6E
2X81
2XNE
2XNG
2XRU
3COH
3E5A
3EFW
3FDN
3H0Y
3H0Z
3H10
3HA6
3K5U
3LAU
3M11
3MYG
3NRM
3O50
3O51
3P9J
3QBN
3R21
3R22
3UNZ
3UO4
3UO5
3UO6
3UOD
3UOH
3UOJ
3UOK
3UOL
3UP2
3UP7
3VAP
3W10
3W16
3W18
3W2C
4B0G
4BN1
4BYI
4BYJ
4C3P
4C3R
4CEG
4DEA
4DEB
4DED
4DEE
4DHF
4J8M
4J8N
4JAI
4JAJ
4JBO
4JBP
4JBQ
4O0S
4O0U
4O0W
4PRJ
4UYN
4UZD
4UZH
4ZS0
4ZTQ
4ZTR
4ZTS
5AAD
5AAE
5AAF
5AAG
5DN3
5DNR
5DOS
5DPV
5DR2
5DR6
5DR9
5DRD
5DT0
5DT3
5DT4
5EW9
5G15
5G1X
5L8J
5L8K
5L8L
5LXM
5OBJ
5OBR
5ODT
5ONE
5ORL
5ORN
5ORO
5ORP
5ORR
5ORS
5ORT
5ORV
5ORW
5ORX
5ORY
5ORZ
5OS0
5OS1
5OS2
5OS3
5OS4
5OS5
5OS6
5OSD
5OSE
5OSF
5ZAN
6C2R
6C2T
6C83
6CPE
6CPF
6CPG
6GRA
6HJJ
6HJK
6I2U
6R49
6R4A
6R4B
6R4C
6R4D
6VPG
6VPH
6VPI
6VPJ
6VPL
6VPM
6XKA
6Z4Y
Enriched GO Terms of Interacting Partners
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