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USP2 and CCDC57
Data Source:
BioGRID
(two hybrid)
USP2
CCDC57
Description
ubiquitin specific peptidase 2
coiled-coil domain containing 57
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Membrane
Perinuclear Region Of Cytoplasm
Centrosome
Centriole
Spindle Microtubule
Centriolar Satellite
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Muscle Organ Development
Protein Deubiquitination
Protein Phosphopantetheinylation
Circadian Regulation Of Gene Expression
Entrainment Of Circadian Clock By Photoperiod
Locomotor Rhythm
Positive Regulation Of Mitotic Cell Cycle
Circadian Behavior
Protein Stabilization
G2/M Transition Of Mitotic Cell Cycle
Microtubule Nucleation
Centriole Replication
Positive Regulation Of Mitotic Cell Cycle
Cilium Assembly
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Regulation of TP53 Degradation
Drugs
Diseases
GWAS
Refractive error (
32231278
)
Serum uric acid levels (
30993211
)
Urate levels (
31985003
31578528
23263486
)
Blood metabolite levels (
24816252
)
Blood urea nitrogen levels (
31152163
)
Proteinuria and chronic kidney disease (
26420894
)
Refractive error (
32231278
)
Interacting Genes
163 interacting genes:
ABI2
ACTN1
ACTN2
ACTN3
APP
ASPG
ATN1
AURKA
BAP1
BCAR1
BCL2L2-PABPN1
BEGAIN
BEND5
BHLHB9
BICD2
BIRC7
BRCA1
CADPS
CALCOCO2
CARD9
CBLC
CCDC136
CCDC57
CCDC85B
CCDC88B
CCND1
CEP63
CEP70
CRACR2A
CRACR2B
CRY1
CTNNB1
DDI1
DEPDC5
DISC1
DTX3
DUSP21
DYDC1
EFHC2
EIF4ENIF1
ENPP1
ERBB2
EXOC5
EXOSC8
GEMIN4
GOLGA2
GOLGA6A
GOLGA6L9
GRB7
GRIPAP1
H2AC20
HOMER3
HOOK1
HOOK2
IHO1
IKBKG
IKZF3
IL1RL2
INTS11
JAKMIP1
JRK
KAZN
KIFC3
KRT15
KRT27
KRT31
KRT33B
KRT34
KRT35
KRT40
LHX3
LHX4
LMNA
LMNB2
LNX2
LONRF1
LRSAM1
LZTS2
MALT1
MAP3K2
MDM2
MID2
MNAT1
MORN5
MRPL28
MTUS2
MYC
NAB2
NDEL1
NEFL
NFKB2
NOTCH1
OIP5
OPTN
ORC3
ORC5
PALB2
PCGF6
PCNA
PEX5
PIBF1
PICK1
PIK3R3
PLA2G2A
PLEKHG4
PNMA1
POU2AF1
PRDM14
PRR5L
RABEP1
RAD18
RBCK1
RFX6
RNF125
RNF126
RNF144B
RNF166
RUNDC3A
S100A10
SH2B2
SNCA
SORBS3
SPAG8
SPDYE4
STAT5B
TAX1BP1
TEKT4
TFIP11
TGFBR1
TLE5
TNFAIP2
TRAF1
TRAF2
TRAF6
TRAIP
TRIM21
TRIM23
TRIM27
TRIM34
TRIM35
TRIM39
TRIM46
TRIM5
TRIM50
TRIM54
TRIM63
TRIM74
TRIM8
TRIM9
TRIP6
UBE2S
UBOX5
USHBP1
USP15
USP21
USP54
VCAM1
VPS28
VPS52
ZAP70
ZBED1
ZIM2
ZRANB1
148 interacting genes:
ABI1
ABI2
ABLIM1
AMOTL2
ANKRD23
AQP1
ARID5A
ARL4A
AXIN1
BCAR3
BEX2
C19orf44
C2CD6
C4orf45
C9orf24
CBX8
CBY2
CCDC120
CCDC33
CDC20B
CEP57L1
CFAP53
COIL
CRTC2
CWF19L2
DCLK2
DISC1
DTX2
ECPAS
EFHC2
EIF3D
EIF4G1
ELOA
EMILIN3
ESS2
FAM107A
FAM161A
FAM161B
FAM228A
FAM50B
FAM90A1
FH
FOXD4L1
FTO
GFAP
GIGYF1
GPBP1
GPKOW
GRPEL1
HAUS1
HBA2
HDX
IHO1
IKZF3
INCA1
INTS2
JRK
KANK2
KIAA0408
KLF1
KLF15
KPRP
KRT4
KRT76
KRTAP13-2
KRTAP13-3
LENG1
LINC00526
LZTS1
MAD1L1
MDM1
MFAP1
MT1E
MYOZ3
NAB2
NAPRT
NCOA5
NELFE
NME4
NUMA1
PAK5
PER1
POM121
PPHLN1
PPP1R18
PPP1R32
PRAM1
PRDM6
PROSER3
PRPF18
PRPF31
PRR3
PSMB4
PTCHD3
PTPN7
RAB3IL1
RASD1
RBM48
RDM1
RINT1
RNF6
ROBO3
RUSC1
RXRB
SFI1
SH3KBP1
SHISA6
SIRPA
SLC25A48
SMG9
SNRNP35
SORBS3
SPRY1
SYT6
TBC1D22B
TCP10L
TFIP11
TFPT
TIMM44
TLE5
TMEM100
TNNI1
TP53BP2
TRIM14
TRIM29
TSEN54
TSGA10IP
TSHZ2
TXLNA
USP15
USP2
UTP14C
VPS52
YJU2
ZBTB4
ZC2HC1C
ZFC3H1
ZGPAT
ZMAT2
ZNF417
ZNF436
ZNF474
ZNF552
ZNF648
ZNF655
ZNF688
ZNF835
ZSWIM3
Entrez ID
9099
284001
HPRD ID
05287
14150
Ensembl ID
ENSG00000036672
ENSG00000176155
Uniprot IDs
O75604
A0A590UJT6
Q2TAC2
PDB IDs
2HD5
2IBI
3NHE
3V6C
3V6E
5XU8
5XVE
6DGF
Enriched GO Terms of Interacting Partners
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